Investigations
What is an Investigation?
In multiple sclerosis, an “energy crisis”, which entails axonal ATP depletion, contributes to neuronal dysfunction and ensuing neurodegeneration. We have identified dysregulation of the TCA cycle and specifically depletion of its pacemaker enzyme, IDH3, as a critical checkpoint of neuronal energy homeostasis. Targeting IDH3, however, leads only to partial reversal of axonal ATP deficits, pointing to further neuroenergetic checkpoints. We now plan to identify these checkpoints and study their ...
Submitter: Camilla Giudici
Studies: A genome-wide in vivo CRISPR screen identifies essential regulators of T..., Phagocyte-mediated synapse removal in cortical neuroinflammation is prom..., Targeting the TCA cycle can ameliorate widespread axonal energy deficien..., Twin study identifies early immunological and metabolic dysregulation of...
Assays: Expression profiling: Bulk RNA-seq (mouse), Expression profiling: Bulk RNA-seq (rat), Expression profiling: scRNA-seq (human), Expression profiling: scRNA-seq (human), Genome wide (GW) and validation CRISPR screens (rat), Shotgun proteomics (mouse)
