Investigations

Despite the critical role of microglia in human brain pathologies, the molecular mechanisms that govern the diverse and context-dependent set of phenotypes are poorly understood. This project will introduce a highly versatile human brain organoid-based in vivo platform for investigating human glial cells that operate within a vascularized human brain-like environment. Using this platform, we aim to dissect the molecular networks that control human microglia cell responses during CNS injury in ...