Investigations
What is an Investigation?
The cerebral cortex contains a special, perineuronally localized population of oligodendrocyte lineage cells with possible functions in connectivity and myelination. We hypothesize that this cell population serves as a reservoir of remyelinating cells after myelin damage. We will apply spatial transcriptome analysis with subcellular resolution in experimental models of demyelination and human tissue from patients with multiple sclerosis to define physiological and pathological states of perineuronal ...
Submitter: Camilla Giudici
Studies: Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis, Pro-inflammatory activation following demyelination is required for myel..., Single-cell spatial transcriptomic profiling defines a pathogenic inflam...
Assays: Expression profiling: Bulk RNA-seq (mouse), Expression profiling: MERFISH Spatial Transcriptomics (human), Expression profiling: MERFISH Spatial Transcriptomics (mouse), Expression profiling: scRNA-seq (human), Expression profiling: scRNA-seq (human), Expression profiling: scRNA-seq (mouse), Expression profiling: snRNA-seq (mouse), Shotgun proteomics (mouse)
