Expression profiling: snRNA-seq (mouse)
SEEK ID: https://goeseek.gwdguser.de/assays/502
Experimental assay
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Investigation: B01 - Function of satellite oligodendrocytes in remyelination
Study: Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis
Assay position:
Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Mouse
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Created: 7th Aug 2026 at 10:29
Last updated: 7th Aug 2026 at 10:32
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Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
The cerebral cortex contains a special, perineuronally localized population of oligodendrocyte lineage cells with possible functions in connectivity and myelination. We hypothesize that this cell population serves as a reservoir of remyelinating cells after myelin damage. We will apply spatial transcriptome analysis with subcellular resolution in experimental models of demyelination and human tissue from patients with multiple sclerosis to define physiological and pathological states of perineuronal ...
Submitter: Camilla Giudici
Studies: Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis, Pro-inflammatory activation following demyelination is required for myel..., Single-cell spatial transcriptomic profiling defines a pathogenic inflam...
Assays: Expression profiling: Bulk RNA-seq (mouse), Expression profiling: MERFISH Spatial Transcriptomics (human), Expression profiling: MERFISH Spatial Transcriptomics (mouse), Expression profiling: scRNA-seq (human), Expression profiling: scRNA-seq (human), Expression profiling: scRNA-seq (mouse), Expression profiling: snRNA-seq (mouse), Shotgun proteomics (mouse)
As tissue-resident macrophages of the central nervous system parenchyma, microglia perform diverse essential functions during homeostasis and perturbations1. They primarily interact with neurons by means of synaptic engulfment and through the rapid elimination of apoptotic cells and non-functional synapses2. Here, by combining unbiased lipidomics and high-resolution spatial lipid imaging, deep single-cell transcriptome analysis and novel cell-type-specific mutants, we identified a previously ...
CNS nuclei were isolated from frozen thalamic specimen, FACS purified, and analyzed with snRNA-seq
CNS nuclei were isolated from frozen thalamic specimen, FACS purified, and analyzed with snRNA-seq
CNS nuclei were isolated from frozen CNS tissue specimen, stained with anti-NeuN and anti-Olig2, FACS purified (DAPI+NeuN-Olig2-), and analyzed with snRNA-seq
