University Medical Center Göttingen
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I am a Ph.D. student in the group of Dr. Laura Zelarayan at the Institute of Pharmacology and Toxicology (UMG). I am working to decipher the transcription factors (TF) involved in the transition to heart failure using a murine model. For that, I am analyzing Single-Cell RNAseq and RNAseq data to find the most critical genes implied in regulating this pathological remodeling. Afterward, an inference based on the transcriptome signature would suggest TF targets. Those targets would be confirmed via ...
Projects: Cardiomyocyte tissues
Institutions: University Medical Center Göttingen
https://orcid.org/0000-0003-0777-6859
Projects: CRC1002: Modulatory Units in Heart Failure, Cardiomyocyte tissues, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells, MBExC: Multiscale Bioimaging, CRC 1565: Molecular mechanisms and interplay of gene expression processes
Institutions: University Medical Center Göttingen
https://orcid.org/0000-0003-1236-0815
Projects: Default Project - for test purposes, CRC1002: Modulatory Units in Heart Failure, Cardiomyocyte tissues, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells, MBExC: Multiscale Bioimaging, CRC 1565: Molecular mechanisms and interplay of gene expression processes, CRC 1690: Disease Mechanisms and Functional Restoration of Sensory and Motor Systems
Institutions: Default Institution, University Medical Center Göttingen, Georg-August-Universität Göttingen
https://orcid.org/0000-0002-9895-2469
For test purposes only.
Projects: Default Project - for test purposes, TAVI test project
Web page: Not specified
Projects: MBExC: Multiscale Bioimaging
Web page: https://www.wikidata.org/wiki/Q48975698
Projects: Cardiomyocyte tissues, 12 months EHM project (Dittrich, Zimmermann)
Web page: Not specified
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
Programme: This Project is not associated with a Programme
Public web page: https://sfb1690.uni-goettingen.de/
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
https://sfb1002.med.uni-goettingen.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/193793266?language=en (DFG Gepris entry) With a prevalence of between two and four percent, heart failure remains one of the most common diseases in Europe. Although tremendous progress has been made in its treatment, the morbidity and mortality of affected patients remains high. Advanced heart failure can still only be treated palliatively.We define modulatory units as cell-based and/or genetic ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://herzzentrum.umg.eu/forschung/forschungsverbuende/sfb-1002/
Start date: 1st Jul 2012
End date: 30th Jun 2024
Programme: Cluster of Excellence
Public web page: https://mbexc.de/
https://gepris.dfg.de/gepris/projekt/469281184
While gene expression was traditionally viewed as a linear pathway of consecutive steps, we now know that genome organization and transcription, RNA processing and modification, RNA-protein complex assembly, translation and quality control are highly interconnected processes. Many cross-regulation events occur even between non-consecutive steps of gene expression, and even between processes taking place in different cellular compartments.
This paradigm ...
Programme: This Project is not associated with a Programme
Public web page: https://sfb1565.uni-goettingen.de/
Cochleae of rodents are imaged with light sheet microscopy and subsequently analyzed using deep learning methods for image segmentation. The segmented data is evaluated with respect to the number and location of synapses, inner hair cells (IHC) and spiral ganglion neurons (SGN).
Programme: This Project is not associated with a Programme
Public web page: Not specified
Start date: 17th Feb 2025
Engineered human myocardium (EHM) is cultivated for up to 12 months and analyzed via different (OMICs) techniques to create a reference dataset for further . Primary researcher is Gesine M. Dittrich from the department of Pharmacology and Toxicology (UMG, head: Prof. W.-H. Zimmermann).
Programme: Other research project backgrounds
Public web page: Not specified
