Studies
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Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer’s disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APPNLGF, we demonstrate that OLs and neurons contribute to Aβ plaque burden. For rapid plaque seeding, excitatory projection neurons must provide a threshold level of Aβ. Ultimately, our findings are relevant for AD ...
Submitter: Camilla Giudici
Investigation: 1 hidden item
Assays: Expression profiling: scRNA-seq (mouse), Expression profiling: snRNA-seq (human), Expression profiling: snRNA-seq (human), Expression profiling: snRNA-seq (mouse)
Understanding the complexity of cellular function within a tissue necessitates the combination of multiple phenotypic readouts. Here, we developed a method that links spatially-resolved gene expression of single cells with their ultrastructural morphology by integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH) and large area volume electron microscopy (EM) on adjacent tissue sections. Using this method, we characterized in situ ultrastructural and transcriptional ...
Submitter: Camilla Giudici
Investigation: A06 - Linking lipid metabolism to inflammation ...
Assays: Expression profiling: Spatial Transcriptomics correlated Electron Micros...
