Expression profiling: snRNA-seq (mouse)
SEEK ID: https://goeseek.gwdguser.de/assays/490
Experimental assay
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Investigation: C01 - EPO/EPOR signalling in the recovery from brain injury and disease
Assay position:
Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Mouse
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Created: 6th Aug 2026 at 13:56
Last updated: 6th Aug 2026 at 14:01
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Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
Erythropoietin (EPO) is a cytokine that serves, independent of hematopoiesis, signalling functions within the brain, where EPO and its receptor are upregulated upon injury. The underlying mechanisms, however, have remained obscure. We aim to understand the roles of EPO/EPOR signalling as checkpoints of brain homeostasis and thereby specifically predict effects of recombinant EPO as a neuroprotective drug. To this end, we will explore the induction/expression of EPO and EPOR at the single cell ...
Submitter: Camilla Giudici
Studies: Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s ..., Oligodendrocytes produce amyloid-β and contribute to plaque formation al...
Assays: Expression profiling: Bulk RNA-seq (mouse), Expression profiling: SuperSeries (mouse), Expression profiling: scRNA-seq (mouse), Expression profiling: snRNA-seq (human), Expression profiling: snRNA-seq (human), Expression profiling: snRNA-seq (mouse), Expression profiling: snRNA-seq (mouse)
Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer’s disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APPNLGF, we demonstrate that OLs and neurons contribute to Aβ plaque burden. For rapid plaque seeding, excitatory projection neurons must provide a threshold level of Aβ. Ultimately, our findings are relevant for AD ...
Brain hemispheres were dissected from 6-month-old animals and subjected to single-nuclei RNA sequencing using 10x genomics Chromium 3’ assay. In total 4 genotypes were included for the experiment (WT, Cnp-/-, 5xFAD, Cnp-/-x5xFAD), each genotype has n=2 replicates.
Brain hemispheres were dissected from 6-month-old animals and subjected to single-nuclei RNA sequencing using 10x genomics Chromium 3’ assay. In total 4 genotypes were included for the experiment (WT, Cnp-/-, 5xFAD, Cnp-/-x5xFAD), each genotype has n=2 replicates.
Cortex and corpus callosum were dissected from every two animals (3-month-old) and pooled into one sample for single-nuclei RNA sequencing using 10x genomics Chromium 3’ assay. Each genotype has 2 replicates (in total n=4 animals).
