Expression profiling: SuperSeries (mouse)
This SuperSeries is composed of the SubSeries listed below.
SEEK ID: https://goeseek.gwdguser.de/assays/511
Experimental assay
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Investigation: C01 - EPO/EPOR signalling in the recovery from brain injury and disease
Study: Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Assay position:
Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Mouse
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Created: 10th Aug 2026 at 12:08
Last updated: 10th Aug 2026 at 12:10
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Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
Erythropoietin (EPO) is a cytokine that serves, independent of hematopoiesis, signalling functions within the brain, where EPO and its receptor are upregulated upon injury. The underlying mechanisms, however, have remained obscure. We aim to understand the roles of EPO/EPOR signalling as checkpoints of brain homeostasis and thereby specifically predict effects of recombinant EPO as a neuroprotective drug. To this end, we will explore the induction/expression of EPO and EPOR at the single cell ...
Submitter: Camilla Giudici
Studies: Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s ..., Oligodendrocytes produce amyloid-β and contribute to plaque formation al...
Assays: Expression profiling: Bulk RNA-seq (mouse), Expression profiling: SuperSeries (mouse), Expression profiling: scRNA-seq (mouse), Expression profiling: snRNA-seq (human), Expression profiling: snRNA-seq (human), Expression profiling: snRNA-seq (mouse), Expression profiling: snRNA-seq (mouse)
The incidence of Alzheimer’s disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocytes and the structural integrity of myelin sheaths1, the latter of which is associated with secondary neuroinflammation2,3. As oligodendrocytes support axonal energy metabolism and neuronal health4,5,6,7, we hypothesized that loss of myelin integrity could be an upstream risk factor for ...
