Skin and gut imprinted T helper cell subsets exhibit distinct functional phenotypes in CNS autoimmunity

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https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...

Compartmentalized inflammatory processes within the CNS might be a driver of tissue damage in chronic stages of CNS autoimmunity. Tissue resident T cells constitute a sizeable population of immune cells in the chronically inflamed CNS. However, little is known about their functional integration into CNS tissue niches. Here, we have identified the co-inhibitory molecule CD96 to be expressed on a subset of CNS resident conventional and regulatory T cells. Using genetic tools, we aim to investigate ...

Multidimensional single cell-analyses of T cells have fueled the debate about either extensive plasticity or “mixed” priming of T helper cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant of T helper cell-induced immunopathology in remote organs. By site-specific in vivo labeling of antigen-specific T cells in inguinal (i) or gut draining mesenteric (m) lymph nodes, we show that i-T cells ...