B03 - Glia-glia interactions as checkpoints of antibody-mediated CNS lesion formation and resolution

In autoantibody-mediated gliopathies, such as Neuromyelitis Optica Spectrum Disorder, pathology often spreads quickly beyond the intital target cell type to affect other glial cells. In this project, we will identify glial-glia interactions that act either as checkpoints of acute pathology spread or as checkpoints of lesion repair. To achieve this, we will use in vivo imaging in animal models, as well as genetic interventions and close correlation with human neuropathology, to study how the dissemination of pathology from one cell type to another could be intercepted and how lesion repair, especially remyelination, could be promoted.