Johanna Klughammer

https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...

Since the first funding period, Z02 has provided comprehensive support for all our research projects, from experimental design to bioinformatics data analysis. We specialize in bulk and single-cell genomic methods, including technologies like 10x Genomics and flow-cytometry based isolation methods. Additionally, we offer training on tissue preparation, single-cell sorting, and the use of 10x Genomics equipment to ensure high-quality data. By centralizing sample preparation, sequencing, and analysis, ...

Although metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly characterized due to technical and biospecimen limitations. In this study, we assembled a multi-modal spatial and cellular map of 67 tumor biopsies from 60 patients with metastatic breast cancer across diverse clinicopathological features and nine anatomic sites with detailed clinical annotations. We combined single-cell or single-nucleus RNA sequencing for all biopsies with a panel ...