T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.
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Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.
SEEK ID: https://goeseek.gwdguser.de/studies/300
Z02 - Genomics and Bioinformatics Platform
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
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Created: 3rd Aug 2026 at 12:19
Last updated: 3rd Aug 2026 at 12:54
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Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
https://orcid.org/0000-0002-9069-2594
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
Since the first funding period, Z02 has provided comprehensive support for all our research projects, from experimental design to bioinformatics data analysis. We specialize in bulk and single-cell genomic methods, including technologies like 10x Genomics and flow-cytometry based isolation methods. Additionally, we offer training on tissue preparation, single-cell sorting, and the use of 10x Genomics equipment to ensure high-quality data. By centralizing sample preparation, sequencing, and analysis, ...
Submitter: Camilla Giudici
Studies: A multi-modal single-cell and spatial expression map of metastatic breas..., CD8+ T cells induce interferon-responsive oligodendrocytes and microglia..., T cell-mediated microglial activation triggers myelin pathology in a mou...
Assays: Data availabilty, Expression profiling: MERFISH Spatial Transcriptomics (mouse), Expression profiling: scRNA-seq (mouse), Expression profiling: scRNA-seq (mouse)
Submitter: Camilla Giudici
Assay type: Transcriptomics
Technology type: Sequencing
Investigation: Z02 - Genomics and Bioinformatics Platform
Brain sections were collected from mouse model of amyloidosis and analyzed by MERFISH
Submitter: Camilla Giudici
Assay type: Transcriptomics
Technology type: Sequencing
Investigation: Z02 - Genomics and Bioinformatics Platform
To determine whether CD8+ T cells contribute to oligodendrocyte and myelin pathology in 5xFAD mice, we treated 6-months old 5xFAD mice with antibodies against CD8. For the depletion of CD8+ T cells mice, 5xFAD mice aged 6 months were intraperitoneally injected with anti-CD8 antibody (BioXCell, BP0061) and their respective isotype controls (BioXCell, BE0119) twice a week for a total of 6 weeks.For 10X genomic experiments, mice were deeply anesthetized and perfused with cold PBS. Each brain was ...
Creators: None
Submitter: Camilla Giudici
Brain sections were collected from mouse model of amyloidosis and analyzed by MERFISH
Creators: None
Submitter: Camilla Giudici
Abstract (Expand)
Authors: Shreeya Kedia, Hao Ji, Ruoqing Feng, Peter Androvic, Lena Spieth, Lu Liu, Jonas Franz, Hanna Zdiarstek, Katrin Perez Anderson, Cem Kaboglu, Qian Liu, Nicola Mattugini, Fatma Cherif, Danilo Prtvar, Ludovico Cantuti-Castelvetri, Arthur Liesz, Martina Schifferer, Christine Stadelmann, Sabina Tahirovic, Ozgun Gokce, Mikael Simons
Date Published: 27th Jun 2024
Publication Type: Journal Article
