T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis

Abstract:

AbstractAge-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer’s disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer’s disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against myelinating oligodendrocytes may contribute to neurodegenerative diseases with amyloidosis.

SEEK ID: https://goeseek.gwdguser.de/publications/13

DOI: 10.1038/s41593-024-01682-8

Projects: TRR 274: Checkpoints of Central Nervous System Recovery

Publication type: Journal Article

Journal: Nature Neuroscience

Book Title: Nature Neuroscience

Publisher: Springer Science and Business Media LLC

Citation: Nat Neurosci 27(8):1468-1474.

Date Published: 27th Jun 2024

Registered Mode: by DOI

Authors: Shreeya Kedia, Hao Ji, Ruoqing Feng, Peter Androvic, Lena Spieth, Lu Liu, Jonas Franz, Hanna Zdiarstek, Katrin Perez Anderson, Cem Kaboglu, Qian Liu, Nicola Mattugini, Fatma Cherif, Danilo Prtvar, Ludovico Cantuti-Castelvetri, Arthur Liesz, Martina Schifferer, Christine Stadelmann, Sabina Tahirovic, Ozgun Gokce, Mikael Simons

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Citation
Kedia, S., Ji, H., Feng, R., Androvic, P., Spieth, L., Liu, L., Franz, J., Zdiarstek, H., Anderson, K. P., Kaboglu, C., Liu, Q., Mattugini, N., Cherif, F., Prtvar, D., Cantuti-Castelvetri, L., Liesz, A., Schifferer, M., Stadelmann, C., Tahirovic, S., … Simons, M. (2024). T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis. In Nature Neuroscience (Vol. 27, Issue 8, pp. 1468–1474). Springer Science and Business Media LLC. https://doi.org/10.1038/s41593-024-01682-8
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Created: 3rd Aug 2026 at 12:20

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