Wahl-lab/Heiser_BrainwideMicrostrokes
Code and sample data supporting Heiser et al. "Brain-wide microstrokes affect the stability of memory circuits in the hippocampus", submitted to Nature Communications. The code and sample data is published for transparency and reproducibility and is not directly executable.
SEEK ID: https://goeseek.gwdguser.de/assays/452
Experimental assay
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Investigation: C06 - Understanding checkpoints of interneuron sculpting for neuronal remodelling of microcircuits to promote CNS repair
Study: Brain-wide microstrokes affect the stability of memo ry circuits in the hippocampus
Assay position:
Assay type: Experimental Assay Type
Technology type: Technology Type
Organisms: No organisms
Export PNG
Download
Creators and Submitter
Views: 15
Created: 4th Aug 2026 at 08:07
Last updated: 4th Aug 2026 at 08:08
TagsThis item has not yet been tagged.
Related items
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
Strokes destroy excitatory inputs – not only in the stroke area, but also in remote regions such as the hippocampus, which may lead to disorganized GABAergic activity and cause cognitive decline. We propose here to identify and modulate checkpoints of GABAergic population dynamics shaping microcircuits of excitatory pyramidal neurons in the hippocampus. We aim at enhancing functional and structural rewiring processes by systematically modulating GABAergic interneuron activity and thus defining ...
Cognitive deficits affect over 70% of stroke survivors, yet the mechanisms by which multiple small ischemic events contribute to cognitive decline remain poorly understood. In this study, we employed chronic two-photon calcium imaging to longitudinally track the fate of individual neurons in the hippocampus of mice navigating a virtual reality environment, both before and after inducing brain-wide microstrokes. Our findings reveal that, under normal conditions, hippocampal neurons exhibit varying ...
