Brain-wide microstrokes affect the stability of memory circuits in the hippocampus

https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...

Strokes destroy excitatory inputs – not only in the stroke area, but also in remote regions such as the hippocampus, which may lead to disorganized GABAergic activity and cause cognitive decline. We propose here to identify and modulate checkpoints of GABAergic population dynamics shaping microcircuits of excitatory pyramidal neurons in the hippocampus. We aim at enhancing functional and structural rewiring processes by systematically modulating GABAergic interneuron activity and thus defining ...

Cognitive deficits affect over 70% of stroke survivors, yet the mechanisms by which multiple small ischemic events contribute to cognitive decline remain poorly understood. In this study, we employed chronic two-photon calcium imaging to longitudinally track the fate of individual neurons in the hippocampus of mice navigating a virtual reality environment, both before and after inducing brain-wide microstrokes. Our findings reveal that, under normal conditions, hippocampal neurons exhibit varying ...