Expression profiling: scRNA-seq (human) (Day 20)
SEEK ID: https://goeseek.gwdguser.de/assays/461
Experimental assay
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Investigation: C05 - Glial checkpoints for neuronal circuitry recovery
Assay position:
Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Human
Export PNG
Download
Creators and Submitter
Views: 20
Created: 4th Aug 2026 at 11:30
Last updated: 6th Aug 2026 at 08:08
TagsThis item has not yet been tagged.
Related items
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
Neuronal loss in acute or chronic brain disease could be treated by neuronal replacement strategies, such as transplantation of young neurons, if they integrate properly into the existing networks. Here we explore the cell-based and molecular mechanisms causing hyperinnervation and overshoot loss of input connectivity as well as the newly discovered hurdle in output connectivity, the lack of myelination. Candidate as well as unbiased approaches are pursued to identify the critical checkpoints and ...
Submitter: Camilla Giudici
Studies: Astrocyte heterogeneity reveals region-specific astrogenesis in the whit..., Brain injury environment critically influences the connectivity of trans..., Direct neuronal reprogramming of NDUFS4 patient cells identifies the unf..., Direct neuronal reprogramming of mouse astrocytes is associated with mul..., Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the..., Injury-specific factors in the cerebrospinal fluid regulate astrocyte pl..., Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astr...
Assays: Expression profiling, Expression profiling by array, Expression profiling: Bulk RNA-seq (human), Expression profiling: Bulk RNA-seq (mouse), Expression profiling: Single-cell multiome (scRNA-seq + scATAC-seq), Bul..., Expression profiling: Spatial Transcriptomics (mouse), Expression profiling: Spatial Transcriptomics (mouse), Expression profiling: scRNA-seq (human) (Day 20), Expression profiling: scRNA-seq (human) (Day 5), Expression profiling: scRNA-seq (mouse), Expression profiling: scRNA-seq (mouse), Expression profiling: scRNA-seq (mouse), Shotgun proteomics (human), Shotgun proteomics (mouse), scRNA-seq and scATAC-seq
Mitochondria account for essential cellular pathways, from ATP production to nucleotide metabolism, and their deficits lead to neurological disorders and contribute to the onset of age-related diseases. Direct neuronal reprogramming aims at replacing neurons lost in such conditions, but very little is known about the impact of mitochondrial dysfunction on the direct reprogramming of human cells. Here, we explore the effects of mitochondrial dysfunction on the neuronal reprogramming of induced ...
pAstros were transduced with control or Ngn2-expressing retrovirus. 2DPT, media was replaced with differentiation media in absence of presence of AMG; 20DPT, DsRed-positive cells were sorted, barcoded with CMOs and analyzed by scRNAseq via 10XGenomics platform.
