A08 - Deciphering the heterogeneity of B-lymphoid subpopulations impacting on CNS recovery from acute multiple sclerosis bouts
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B lymphocytes have been more recently recognized to possess a dual role in MS pathogenesis. On the one hand, B cells promote inflammation of the central nervous system and MS progression, while on the other hand, B-lymphoid inhibition of pathogenic T cell functions ameliorates MS severity and facilitates recovery from acute MS bouts. To understand the functional dichotomy, we aim at a comprehensive phenotyping of individual B cell subpopulations followed by their transcriptional profiling to better understand the molecular checkpoints of B cell specification.
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Created: 3rd Aug 2026 at 08:37
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Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
To investigate TFEB-dependent expression in BCR-stimulated and resting B cells, CRISPR/Cas9 knockout cell lines were established and subjected to RNA sequencing analysis
Submitter: Camilla Giudici
Assay type: Transcriptomics
Technology type: Sequencing
Investigation: A08 - Deciphering the heterogeneity of B-lympho...
Submitter: Camilla Giudici
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: A08 - Deciphering the heterogeneity of B-lympho...
Submitter: Camilla Giudici
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: A08 - Deciphering the heterogeneity of B-lympho...
Submitter: Camilla Giudici
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: A08 - Deciphering the heterogeneity of B-lympho...
Creators: None
Submitter: Camilla Giudici
To investigate TFEB-dependent mRNA expression in murine B cells, FACS-sorted germinal center and non-germinal center B lymphocytes of B-cell-specific conditional TFEB KO mice and control littermates were subjected to RNA sequencing analysis
Creators: None
Submitter: Camilla Giudici
Creators: None
Submitter: Camilla Giudici
Creators: None
Submitter: Camilla Giudici
Abstract (Expand)
Authors: Matthias Münchhalfen, Richard Görg, Michael Haberl, Jens Löber, Jakob Willenbrink, Laura Schwarzt, Charlotte Höltermann, Christian Ickes, Leonard Hammermann, Jan Kus, Björn Chapuy, Andrea Ballabio, Sybille D. Reichardt, Alexander Flügel, Niklas Engels, Jürgen Wienands
Date Published: 14th Aug 2024
Publication Type: Journal Article
