Arianna Merlini

https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...

The meninges are an important anatomical checkpoint for CNS autoinflammatory diseases, as this is where immune cells are recruited and where they can chronically persist. We propose that CNS persistent inflammation alters the meningeal milieu, particularly the vessels, creating a chronic inflammatory environment. This sustained inflammation impedes CNS recovery from acute damage. Our research aims to identify, in animal models and human samples of multiple sclerosis, cells and factors in the ...