A04 - The role of the meninges in the resolution of acute autoimmune CNS lesions
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The meninges are an important anatomical checkpoint for CNS autoinflammatory diseases, as this is where immune cells are recruited and where they can chronically persist. We propose that CNS persistent inflammation alters the meningeal milieu, particularly the vessels, creating a chronic inflammatory environment. This sustained inflammation impedes CNS recovery from acute damage. Our research aims to identify, in animal models and human samples of multiple sclerosis, cells and factors in the meninges that drive chronic inflammation in MS, ultimately identifying new drug targets for CNS recovery.
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Created: 6th Aug 2026 at 14:12
Last updated: 6th Aug 2026 at 14:13
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Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
https://orcid.org/0000-0002-9567-2250
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune disease of the central nervous system1. In addition, the lung serves as a niche for the disease-inducing T cells for long-term survival and for maturation into migration-competent effector T cells2. Why the lung tissue in particular has such an important role in an autoimmune disease of the brain is not yet known. Here we detected a tight interconnection between the lung microbiota and the immune ...
Submitter: Camilla Giudici
Investigation: A04 - The role of the meninges in the resolutio...
Submitter: Camilla Giudici
Assay type: Transcriptomics
Technology type: Sequencing
Investigation: A04 - The role of the meninges in the resolutio...
In order to investigate the effect of antibiotic treatment on the bacterial communities of lung and gut, we performed an amplicon-based analysis of bronchoalveolar lavage fluid and feces from wild type LEW/Crl rats (Rattus norvegicus) after 7 days of intratracheal or per os treatment with PBS, neomycin or vancomycin.
Creators: None
Submitter: Camilla Giudici
In order to investigate the effect of antibiotics on the CNS, we performed a RNA-Seq analysis on spinal cord-derived microglia and total spinal cord from wild type LEW/Crl rats (Rattus norvegicus) after 7 days of intratracheal treatment with PBS, neomycin (NEO) or vancomycin (VANCO).
Creators: None
Submitter: Camilla Giudici
In order to investigate the effect of antibiotics on the expression profile of T cells, RNA-Seq analysis was performed on MBP-reactive T cells sorted from the lungs of LEW/Crl rats (Rattus norvegicus) intratracheally pre-treated for 7 days with PBS or NEO. Analyis was performed on day 0 and day 1 after intratacheal immunization with MBP.
Creators: None
Submitter: Camilla Giudici
Abstract (Expand)
Authors: L. Hosang, R. C. Canals, F. J. van der Flier, J. Hollensteiner, R. Daniel, A. Flugel, F. Odoardi
Date Published: 25th Feb 2022
Publication Type: Journal Article
