Expression profiling: Bulk RNA-seq (human)
SEEK ID: https://goeseek.gwdguser.de/assays/485
Experimental assay
Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Investigation: hidden item
Study: Innate immune memory after brain injury drives inflammatory cardiac dysfunction
Assay position:
Assay type: Transcriptomics
Technology type: Sequencing
Organisms: Human
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Created: 6th Aug 2026 at 08:34
Last updated: 6th Aug 2026 at 08:35
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Projects: TRR 274: Checkpoints of Central Nervous System Recovery
Institutions: Universitätsmedizin Göttingen
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://www.sfb274.de/
The medical burden of stroke extends beyond the brain injury itself and is largely determined by chronic comorbidities that develop secondarily. We hypothesized that these comorbidities might share a common immunological cause, yet chronic effects post-stroke on systemic immunity are underexplored. Here, we identify myeloid innate immune memory as a cause of remote organ dysfunction after stroke. Single-cell sequencing revealed persistent pro-inflammatory changes in monocytes/macrophages in ...
Submitter: Camilla Giudici
Investigation: 1 hidden item
Assays: Expression profiling: Bulk RNA-seq (human), Expression profiling: scRNA-seq (mouse), Genome binding/occupancy profiling: Bulk ATAC-seq (mouse), Genome binding/occupancy profiling: CUT&Tag sequencing (mouse), Genome binding/occupancy profiling: snATAC-seq (mouse)
Bulk mRNA sequencing of human heart paraffin embeded samples from stroke patients and control patients
