T cell mediated microglia activation triggers myelin pathology in a model of amyloidosis [MERFISH]

Version 1

https://rdp.sfb274.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/408885537 (DFG Gepris entry) The central nervous system (CNS) is a terminally differentiated tissue, where any insult carries a heightened risk - yet the tissue response to these insults is variable and can range from irreversible destruction to almost complete recovery. The rules that instruct these divergent outcomes are still unknown. The aim of this CRC is therefore to understand the biology of the multicellular ...

Since the first funding period, Z02 has provided comprehensive support for all our research projects, from experimental design to bioinformatics data analysis. We specialize in bulk and single-cell genomic methods, including technologies like 10x Genomics and flow-cytometry based isolation methods. Additionally, we offer training on tissue preparation, single-cell sorting, and the use of 10x Genomics equipment to ensure high-quality data. By centralizing sample preparation, sequencing, and analysis, ...

Age-related myelin damage induces inflammatory responses, yet its involvement in Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a mouse model of Alzheimer's disease, we found that amyloidosis itself triggers age-related oligodendrocyte and myelin damage. Mechanistically, CD8+ T cells promote the progressive accumulation of abnormally interferon-activated microglia that display myelin-damaging activity. Thus, our data suggest that immune responses against ...