SEEK ID: https://goeseek.gwdguser.de/assays/4
Experimental assay
Projects: CRC1002: Modulatory Units in Heart Failure
Investigation: CRC1002 Project C07 (2016-2024)
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Assay type: Experimental Assay Type
Technology type: Technology Type
Organisms: No organisms
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Created: 2nd Feb 2022 at 14:37
Last updated: 2nd Feb 2022 at 14:48
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Projects: Default Project - for test purposes, CRC1002: Modulatory Units in Heart Failure, Cardiomyocyte tissues, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells, MBExC: Multiscale Bioimaging, CRC 1565: Molecular mechanisms and interplay of gene expression processes
Institutions: Default Institution, University Medical Center Göttingen, Georg-August-Universität Göttingen
https://orcid.org/0000-0002-9895-2469Expertise: Data Management, Bioinformatics, Molecular Biology, Microbiology
Tools: Proteomics, sequencing, RNA-seq, Genomics
Projects: CRC1002: Modulatory Units in Heart Failure
Institutions: University Medical Center Göttingen
https://orcid.org/0000-0002-9001-0346Expertise: Cardiology, Molecular Biology, Bioinformatics
Tools: sequencing
Projects: CRC1002: Modulatory Units in Heart Failure, TRR 274: Checkpoints of Central Nervous System Recovery, SFB 1190: Compartmental Gates and Contact Sites in Cells
Web page: Not specified
https://sfb1002.med.uni-goettingen.de/ (Research Data Platform) https://gepris.dfg.de/gepris/projekt/193793266?language=en (DFG Gepris entry) With a prevalence of between two and four percent, heart failure remains one of the most common diseases in Europe. Although tremendous progress has been made in its treatment, the morbidity and mortality of affected patients remains high. Advanced heart failure can still only be treated palliatively.We define modulatory units as cell-based and/or genetic ...
Programme: Sonderforschungsbereiche/Collaborative Research Centers
Public web page: https://herzzentrum.umg.eu/forschung/forschungsverbuende/sfb-1002/
Start date: 1st Jul 2012
End date: 30th Jun 2024
https://gepris.dfg.de/gepris/projekt/318243743 Title: Wnt/beta-catenin/TCF-dependent transcriptional regulation in heart failure (Wnt/beta-catenin/TCF-abhängige Transkriptionsregulation in der Herzinsuffizienz) Wnt/ß-catenin activation results in the development of cardiac dysfunction. In this project, the hypothesis will be tested that enhanced Wnt/ß-catenin activity triggers a cell-specific gene expression programs in cardiomyocytes (CM) and cardiac fibroblasts (FB), which contribute to ...
Submitter: Harald Kusch
Studies: A context-specific cardiac Beta-catenin and GATA4 interaction influences...
Assays: ChIP Seq, RNA Seq, echocardiographic analysis, immunocytochemistry
Snapshots: No snapshots
Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Corresponding publication:
https://sfb1002.med.uni-goettingen.de/production/literature/publications/201
(https://doi.org/10.1093/nar/gky049)
Submitter: Harald Kusch
Investigation: CRC1002 Project C07 (2016-2024)
Assays: ChIP Seq, RNA Seq, echocardiographic analysis, immunocytochemistry
Snapshots: No snapshots
Abstract (Expand)
Authors: L. M. Iyer, S. Nagarajan, M. Woelfer, E. Schoger, S. Khadjeh, M. P. Zafiriou, V. Kari, J. Herting, S. T. Pang, T. Weber, F. S. Rathjens, T. H. Fischer, K. Toischer, G. Hasenfuss, C. Noack, S. A. Johnsen, L. C. Zelarayan
Date Published: 6th Apr 2018
Publication Type: Journal
PubMed ID: 29394407
Citation: Nucleic Acids Res. 2018 Apr 6;46(6):2850-2867. doi: 10.1093/nar/gky049.