CRC1002 Project C07 (2016-2024)
Title: Wnt/beta-catenin/TCF-dependent transcriptional regulation in heart failure (Wnt/beta-catenin/TCF-abhängige Transkriptionsregulation in der Herzinsuffizienz)
Wnt/ß-catenin activation results in the development of cardiac dysfunction. In this project, the hypothesis will be tested that enhanced Wnt/ß-catenin activity triggers a cell-specific gene expression programs in cardiomyocytes (CM) and cardiac fibroblasts (FB), which contribute to disease progression. We will define both (I) the consequences of Wnt/ß-catenin activation and (II) the effect of ß-catenin loss of function at different stages of disease progression upon pressure overload in CM und FB in the mouse. Wnt components will be analysed in myocardium patient samples with aortic stenosis. (III) We will also test the suitability of a specific inhibition of the Wnt/ß-catenin /TCF7L2-dependent transcriptional activity to prevent heart failure progression.

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Created: 2nd Feb 2022 at 13:56

Last updated: 23rd Aug 2023 at 15:13

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