Technology type 'Technology Type'
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Related assays
4 Assays visible to you, out of a total of 308Activation of the evolutionarily conserved, developmental Wnt pathway has been reported during maladaptive cardiac remodeling. Although the function of Wnt-transcriptional activation in development is well described, the consequences of Wnt pathway activation, as well as its cardiac-specific regulatory role in the adult heart, is largely unknown. We show that β-catenin and Transcription factor 7-like 2 (TCF7L2), the main nuclear components of the Wnt-transcriptional cascade, and their transcriptional ...
Submitter: Harald Kusch
Assay type: Gene Expression Profiling
Technology type: Chip-seq
Investigation: CRC1002 Project C07 (2016-2024)
Summary: Activation of the evolutionarily conserved, developmental Wnt pathway has been reported during maladaptive cardiac remodeling. Although the function of Wnt-transcriptional activation in development is well described, the consequences of Wnt pathway activation, as well as its cardiac-specific regulatory role in the adult heart, is largely unknown. We show that β-catenin and Transcription factor 7-like 2 (TCF7L2), the main nuclear components of the Wnt-transcriptional cascade, and their ...
Submitter: Harald Kusch
Assay type: Gene Expression Profiling
Technology type: Rna-seq
Investigation: CRC1002 Project C07 (2016-2024)
Transaortic constriction (TAC) was done in 12-weeks-old mice. Pre-anesthetic and anesthetic agents are listed in Supplemental Table S2. The intervention was performed by tying a braided 5–0 polyviolene suture (Hugo Sachs Electronik) ligature around the aorta and a blunted 26-gauge needle and subsequent removal of the needle. For sham controls, the suture was not tied. To determine the level of pressure overload by aortic ligation, a high frequency Doppler probe was used to measure the ratio between ...
Submitter: Harald Kusch
Assay type: Echocardiographic analysis
Technology type: micro-ultrasound imaging
Investigation: CRC1002 Project C07 (2016-2024)
Submitter: Harald Kusch
Assay type: Experimental Assay Type
Technology type: Technology Type
Investigation: CRC1002 Project C07 (2016-2024)