Technology type 'Technology Type'

Related assays

75 Assays visible to you, out of a total of 520

CRC1002: Modulatory Units in Heart Failure

Activation of the evolutionarily conserved, developmental Wnt pathway has been reported during maladaptive cardiac remodeling. Although the function of Wnt-transcriptional activation in development is well described, the consequences of Wnt pathway activation, as well as its cardiac-specific regulatory role in the adult heart, is largely unknown. We show that β-catenin and Transcription factor 7-like 2 (TCF7L2), the main nuclear components of the Wnt-transcriptional cascade, and their transcriptional ...

Submitter: Harald Kusch

Assay type: Gene Expression Profiling

Technology type: Chip-seq

Investigation: CRC1002 Project C07 (2016-2024)

Study: A context-specific cardiac Beta-catenin and GAT...

Organisms: No organisms

SOPs: No SOPs

Data files: 1 hidden item

Snapshots: No snapshots

Created: 2nd Feb 2022 at 14:33, Last updated: 2nd Feb 2022 at 15:53

CRC1002: Modulatory Units in Heart Failure

Summary: Activation of the evolutionarily conserved, developmental Wnt pathway has been reported during maladaptive cardiac remodeling. Although the function of Wnt-transcriptional activation in development is well described, the consequences of Wnt pathway activation, as well as its cardiac-specific regulatory role in the adult heart, is largely unknown. We show that β-catenin and Transcription factor 7-like 2 (TCF7L2), the main nuclear components of the Wnt-transcriptional cascade, and their ...

Submitter: Harald Kusch

Assay type: Gene Expression Profiling

Technology type: Rna-seq

Investigation: CRC1002 Project C07 (2016-2024)

Study: A context-specific cardiac Beta-catenin and GAT...

Organisms: No organisms

SOPs: No SOPs

Data files: 3 hidden items

Snapshots: No snapshots

Created: 2nd Feb 2022 at 14:34, Last updated: 2nd Feb 2022 at 15:56

echocardiographic analysis

CRC1002: Modulatory Units in Heart Failure

Transaortic constriction (TAC) was done in 12-weeks-old mice. Pre-anesthetic and anesthetic agents are listed in Supplemental Table S2. The intervention was performed by tying a braided 5–0 polyviolene suture (Hugo Sachs Electronik) ligature around the aorta and a blunted 26-gauge needle and subsequent removal of the needle. For sham controls, the suture was not tied. To determine the level of pressure overload by aortic ligation, a high frequency Doppler probe was used to measure the ratio between ...

Submitter: Harald Kusch

Assay type: Echocardiographic analysis

Technology type: micro-ultrasound imaging

Investigation: CRC1002 Project C07 (2016-2024)

Study: A context-specific cardiac Beta-catenin and GAT...

Organisms: No organisms

SOPs: No SOPs

Data files: 1 hidden item

Snapshots: No snapshots

Created: 2nd Feb 2022 at 14:35, Last updated: 2nd Feb 2022 at 15:57

immunocytochemistry

CRC1002: Modulatory Units in Heart Failure

No description specified

Submitter: Harald Kusch

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: CRC1002 Project C07 (2016-2024)

Study: A context-specific cardiac Beta-catenin and GAT...

Organisms: No organisms

SOPs: No SOPs

Data files: 1 hidden item

Snapshots: No snapshots

Created: 2nd Feb 2022 at 14:37, Last updated: 2nd Feb 2022 at 14:48

Expression profiling: scRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: A01 - CD96 as checkpoint for the persistence of...

Study: Skin and gut imprinted helper T cell subsets ex...

Organisms: Human

SOPs: No SOPs

Data files: CSF CD4 T cells in MS

Snapshots: No snapshots

Created: 6th Jul 2026 at 12:48, Last updated: 3rd Aug 2026 at 11:50

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: A01 - CD96 as checkpoint for the persistence of...

Study: Skin and gut imprinted helper T cell subsets ex...

Organisms: Mouse

SOPs: No SOPs

Data files: Tracking of CD4+ T cells during CNS autoimmunity

Snapshots: No snapshots

Created: 6th Jul 2026 at 13:13, Last updated: 6th Aug 2026 at 08:38

Expression profiling: Bulk RNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Gene Expression Profiling

Technology type: Rna-seq

Investigation: A01 - CD96 as checkpoint for the persistence of...

Study: Skin and gut imprinted helper T cell subsets ex...

Organisms: Mouse

SOPs: No SOPs

Data files: Skin and gut imprinted T helper cell subsets ex...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 11:42, Last updated: 6th Aug 2026 at 08:38

Genome binding/occupancy profiling: Bulk ATAC-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: A01 - CD96 as checkpoint for the persistence of...

Study: Skin and gut imprinted helper T cell subsets ex...

Organisms: Mouse

SOPs: No SOPs

Data files: Skin and gut imprinted T helper cell subsets ex...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 11:56, Last updated: 6th Aug 2026 at 08:39

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: 1 hidden item

Study: T cells modulate the microglial response to bra...

Organisms: Mouse

SOPs: No SOPs

Data files: T cells modulate the microglial response to bra...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 12:26, Last updated: 6th Aug 2026 at 08:16

Expression profiling: MERFISH Spatial Transcriptomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: Z02 - Genomics and Bioinformatics Platform

Study: T cell-mediated microglial activation triggers ...

Organisms: Mouse

SOPs: No SOPs

Data files: T cell mediated microglia activation triggers m...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 12:31, Last updated: 6th Aug 2026 at 08:04

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

Brain sections were collected from mouse model of amyloidosis and analyzed by MERFISH

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: Z02 - Genomics and Bioinformatics Platform

Study: T cell-mediated microglial activation triggers ...

Organisms: Mouse

SOPs: No SOPs

Data files: T cell mediated microglia activation triggers m...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 12:34, Last updated: 6th Aug 2026 at 08:05

Expression profiling: scRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

To investigate TFEB-dependent expression in BCR-stimulated and resting B cells, CRISPR/Cas9 knockout cell lines were established and subjected to RNA sequencing analysis

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: A08 - Deciphering the heterogeneity of B-lympho...

Study: TFEB activation hallmarks antigenic experience ...

Organisms: Human

SOPs: No SOPs

Data files: The influence of the transcription factor EB fo...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 13:03, Last updated: 3rd Aug 2026 at 13:06

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: A08 - Deciphering the heterogeneity of B-lympho...

Study: TFEB activation hallmarks antigenic experience ...

Organisms: Mouse

SOPs: No SOPs

Data files: WEHI-231 wt 6h_1

Snapshots: No snapshots

Created: 3rd Aug 2026 at 13:07, Last updated: 6th Aug 2026 at 08:14

Expression profiling by high throughput sequencing (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: A08 - Deciphering the heterogeneity of B-lympho...

Study: TFEB activation hallmarks antigenic experience ...

Organisms: Mouse

SOPs: No SOPs

Data files: The influence of TFEB on gene expression in pri...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 13:11, Last updated: 6th Aug 2026 at 08:14

The B cell receptor-inducible translocatome

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: A08 - Deciphering the heterogeneity of B-lympho...

Study: TFEB activation hallmarks antigenic experience ...

Organisms: Mouse

SOPs: No SOPs

Data files: Transcription factor EB sets the stage for fate...

Snapshots: No snapshots

Created: 3rd Aug 2026 at 13:14, Last updated: 6th Aug 2026 at 08:15

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: Z02 - Genomics and Bioinformatics Platform

Study: CD8+ T cells induce interferon-responsive oligo...

Organisms: Mouse

SOPs: No SOPs

Data files: CD8+ T cells induce interferon-responsive oligo...

Snapshots: No snapshots

Created: 4th Aug 2026 at 07:56, Last updated: 6th Aug 2026 at 08:04

Wahl-lab/Heiser_BrainwideMicrostrokes

TRR 274: Checkpoints of Central Nervous System Recovery

Code and sample data supporting Heiser et al. "Brain-wide microstrokes affect the stability of memory circuits in the hippocampus", submitted to Nature Communications. The code and sample data is published for transparency and reproducibility and is not directly executable.

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: C06 - Understanding checkpoints of interneuron ...

Study: Brain-wide microstrokes affect the stability of...

Organisms: No organisms

SOPs: No SOPs

Data files: Wahl-lab/Heiser_BrainwideMicrostrokes: Publication

Snapshots: No snapshots

Created: 4th Aug 2026 at 08:07, Last updated: 4th Aug 2026 at 08:08

Brain-wide microstrokes affect the stability of memory circuits in the hippocampus

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: C06 - Understanding checkpoints of interneuron ...

Study: Brain-wide microstrokes affect the stability of...

Organisms: No organisms

SOPs: No SOPs

Data files: https://dandiarchive.org/dandiset/001184/0.2408...

Snapshots: No snapshots

Created: 4th Aug 2026 at 08:09, Last updated: 4th Aug 2026 at 08:10

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: C06 - Understanding checkpoints of interneuron ...

Study: Brain-wide microstrokes affect the stability of...

Organisms: No organisms

SOPs: No SOPs

Data files: Raw Data

Snapshots: No snapshots

Created: 4th Aug 2026 at 08:10, Last updated: 4th Aug 2026 at 08:11

Expression profiling: Single-cell multiome (scRNA-seq + scATAC-seq), Bulk ATAC-seq, Bulk RNA-seq, ChIP-seq, Cut&Run, Methyl-HiC (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Direct neuronal reprogramming of mouse astrocyt...

Organisms: Mouse

SOPs: No SOPs

Data files: Direct neuronal reprogramming of mouse astrocyt...

Snapshots: No snapshots

Created: 4th Aug 2026 at 08:18, Last updated: 6th Aug 2026 at 08:06

scRNA-seq and scATAC-seq

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Direct neuronal reprogramming of mouse astrocyt...

Organisms: Mouse

SOPs: No SOPs

Data files: Multimodal profiling of the transcriptional reg...

Snapshots: No snapshots

Created: 4th Aug 2026 at 08:21, Last updated: 6th Aug 2026 at 08:06

Expression profiling

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Direct neuronal reprogramming of mouse astrocyt...

Organisms: Mouse

SOPs: No SOPs

Data files: Multimodal profiling of the transcriptional reg...

Snapshots: No snapshots

Created: 4th Aug 2026 at 08:25, Last updated: 6th Aug 2026 at 08:07

Expression profiling by array

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Microarray

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Direct neuronal reprogramming of mouse astrocyt...

Organisms: Mouse

SOPs: No SOPs

Data files: Tbr2 and Neurog2 occupancy and transcriptional ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 08:27, Last updated: 6th Aug 2026 at 08:07

Expression profiling: Bulk RNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Direct neuronal reprogramming of NDUFS4 patient...

Organisms: Human

SOPs: No SOPs

Data files: Unfolded protein Response is a major hurdle in ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:26, Last updated: 6th Aug 2026 at 08:08

Expression profiling: scRNA-seq (human) (Day 5)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Direct neuronal reprogramming of NDUFS4 patient...

Organisms: Human

SOPs: No SOPs

Data files: Unfolded protein Response is a major hurdle in ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:28, Last updated: 6th Aug 2026 at 08:08

Expression profiling: scRNA-seq (human) (Day 20)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Direct neuronal reprogramming of NDUFS4 patient...

Organisms: Human

SOPs: No SOPs

Data files: Unfolded protein Response is a major hurdle in ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:30, Last updated: 6th Aug 2026 at 08:08

Expression profiling: Spatial Transcriptomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Astrocyte heterogeneity reveals region-specific...

Organisms: Mouse

SOPs: No SOPs

Data files: Spatial transcriptomic of mus musculus: adult c...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:35, Last updated: 6th Aug 2026 at 08:09

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Astrocyte heterogeneity reveals region-specific...

Organisms: Mouse

SOPs: No SOPs

Data files: Region-specific astrocyte heterogeneity in the ..., Shiny-based web visualisation: Astrocyte hetero...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:37, Last updated: 6th Aug 2026 at 08:09

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B05 - Cross-talk between innate immunity and ex...

Study: Shared inflammatory glial cell signature after ...

Organisms: Mouse

SOPs: No SOPs

Data files: Shared inflammatory glial cell signature after ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:40, Last updated: 6th Aug 2026 at 08:12

Expression profiling: Spatial Transcriptomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B05 - Cross-talk between innate immunity and ex...

Study: Shared inflammatory glial cell signature after ...

Organisms: Mouse

SOPs: No SOPs

Data files: Shared inflammatory glial cell signature after ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:41, Last updated: 6th Aug 2026 at 08:12

Shotgun proteomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Technology Type

Investigation: C02 - In vivo detection and targeting of neuroe...

Study: Targeting the TCA cycle can ameliorate widespre...

Organisms: Mouse

SOPs: No SOPs

Data files: Mitoproteomics of neuronal mitochondria of EAE ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:49, Last updated: 6th Aug 2026 at 08:01

Expression profiling: scRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C02 - In vivo detection and targeting of neuroe...

Study: Twin study identifies early immunological and m...

Organisms: Human

SOPs: No SOPs

Data files: Twin study identifies early immunological and m...

Snapshots: No snapshots

Created: 4th Aug 2026 at 11:56, Last updated: 6th Aug 2026 at 08:02

Expression profiling (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B06 - Unmasking molecular networks that orchest...

Study: A scalable human-zebrafish xenotransplantation ...

Organisms: Human

SOPs: No SOPs

Data files: A scalable human-zebrafish xenotransplantation ...

Snapshots: No snapshots

Created: 4th Aug 2026 at 12:06, Last updated: 6th Aug 2026 at 08:12

Data availabilty

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Technology Type

Investigation: Z02 - Genomics and Bioinformatics Platform

Study: A multi-modal single-cell and spatial expressio...

Organisms: No organisms

SOPs: No SOPs

Data files: All data, Transcriptome reference, cellxgene

Snapshots: No snapshots

Created: 4th Aug 2026 at 12:16, Last updated: 4th Aug 2026 at 12:23

Shotgun proteomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Technology Type

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Brain injury environment critically influences ...

Organisms: Mouse

SOPs: No SOPs

Data files: The injury environment critically influences th...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:03, Last updated: 6th Aug 2026 at 08:09

Expression profiling: Bulk RNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Heterogeneity of neurons reprogrammed from spin...

Organisms: Mouse

SOPs: No SOPs

Data files: Early induction of neurogenic program by Ascl1E..., Transcriptional profile (RNA-seq) of cultured a...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:07, Last updated: 6th Aug 2026 at 08:09

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Heterogeneity of neurons reprogrammed from spin...

Organisms: Mouse

SOPs: No SOPs

Data files: Single cell RNA-seq analysis of astrocyte to ne..., Single cell RNA-seq analysis of reprogrammed ne...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:10, Last updated: 6th Aug 2026 at 08:10

Shotgun proteomics (human)

TRR 274: Checkpoints of Central Nervous System Recovery

Total protein content of CSF samples was measured by Bradford assay (BioRad, Feldkirchen, Germany)and 10μg per sample were proteolysed by the commercially available in-StageTip-NHS kit (PreOmics GmbH, Martinsried, Germany) according to the manufacturer's protocol. Briefly, CSF was reduced and alkylated and incubated for 3 hrs at 37°C with Lys-C and trypsin. Resulting peptides were dried for short term storage at -80°C. Prior to measurement, peptides were resuspended in 2% acetonitrile and 0.5% ...

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Technology Type

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Injury-specific factors in the cerebrospinal fl...

Organisms: Human

SOPs: No SOPs

Data files: Injury-specific factors in the cerebrospinal fl...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:15, Last updated: 6th Aug 2026 at 08:10

Expression profiling: Microarray (zebrafish)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Microarray

Investigation: B05 - Cross-talk between innate immunity and ex...

Study: Innate Immune Pathways Promote Oligodendrocyte ...

Organisms: No organisms

SOPs: No SOPs

Data files: Activation of innate immune pathways after brai...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:20, Last updated: 6th Aug 2026 at 07:21

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Single Cell Deletion of the Transcription Facto...

Organisms: Mouse

SOPs: No SOPs

Data files: Single cell deletion of the transcription facto...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:25, Last updated: 6th Aug 2026 at 08:10

Expression profiling: Spatial Transcriptomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C05 - Glial checkpoints for neuronal circuitry ...

Study: Single Cell Deletion of the Transcription Facto...

Organisms: Mouse

SOPs: No SOPs

Data files: Single cell deletion of the transcription facto...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:27, Last updated: 6th Aug 2026 at 08:11

Expression profiling: Bulk RNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C02 - In vivo detection and targeting of neuroe...

Study: Phagocyte-mediated synapse removal in cortical ...

Organisms: Mouse

SOPs: No SOPs

Data files: Local calcium accumulations promote phagocyte-m...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:40, Last updated: 6th Aug 2026 at 08:03

Genome wide (GW) and validation CRISPR screens (rat)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: CRISPR Screen

Technology type: Technology Type

Investigation: C02 - In vivo detection and targeting of neuroe...

Study: A genome-wide in vivo CRISPR screen identifies ...

Organisms: Rat

SOPs: No SOPs

Data files: Genome wide (GW) and validation CRISPR screens ...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:46, Last updated: 6th Aug 2026 at 08:00

Expression profiling: scRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C02 - In vivo detection and targeting of neuroe...

Study: A genome-wide in vivo CRISPR screen identifies ...

Organisms: Human

SOPs: No SOPs

Data files: scRNAseq of blood and CSF CD4+ T cells from MS ...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:47, Last updated: 6th Aug 2026 at 08:01

Expression profiling: Bulk RNA-seq (rat)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C02 - In vivo detection and targeting of neuroe...

Study: A genome-wide in vivo CRISPR screen identifies ...

Organisms: Rat

SOPs: No SOPs

Data files: Effect of Grk2 (spleen, rat) or Ets1 (spleen an...

Snapshots: No snapshots

Created: 6th Aug 2026 at 07:49, Last updated: 6th Aug 2026 at 08:01

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: 1 hidden item

Study: Innate immune memory after brain injury drives ...

Organisms: Mouse

SOPs: No SOPs

Data files: Innate immune memory after brain injury drives ..., Innate immune memory after brain injury drives ..., Innate immune memory after brain injury drives ..., Innate immune memory after brain injury drives ...

Snapshots: No snapshots

Created: 6th Aug 2026 at 08:17, Last updated: 6th Aug 2026 at 08:23

Genome binding/occupancy profiling: snATAC-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Epigenomics

Technology type: Technology Type

Investigation: 1 hidden item

Study: Innate immune memory after brain injury drives ...

Organisms: Mouse

SOPs: No SOPs

Data files: Innate immune memory after brain injury drives ...

Snapshots: No snapshots

Created: 6th Aug 2026 at 08:24, Last updated: 6th Aug 2026 at 08:26

Genome binding/occupancy profiling: Bulk ATAC-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Epigenomics

Technology type: Sequencing

Investigation: 1 hidden item

Study: Innate immune memory after brain injury drives ...

Organisms: Mouse

SOPs: No SOPs

Data files: Innate immune memory after brain injury drives ...

Snapshots: No snapshots

Created: 6th Aug 2026 at 08:26, Last updated: 6th Aug 2026 at 08:28

Expression profiling: Bulk RNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: 1 hidden item

Study: Innate immune memory after brain injury drives ...

Organisms: Human

SOPs: No SOPs

Data files: Innate immune memory after brain injury drives ...

Snapshots: No snapshots

Created: 6th Aug 2026 at 08:34, Last updated: 6th Aug 2026 at 08:35

Genome binding/occupancy profiling: CUT&Tag sequencing (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Epigenomics

Technology type: Sequencing

Investigation: 1 hidden item

Study: Innate immune memory after brain injury drives ...

Organisms: Mouse

SOPs: No SOPs

Data files: Innate immune memory after brain injury drives ...

Snapshots: No snapshots

Created: 6th Aug 2026 at 08:36, Last updated: 6th Aug 2026 at 08:37

Bottom-up proteomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Mass Spectrometry

Investigation: A06 - Linking lipid metabolism to inflammation ...

Study: Nonvesicular lipid transfer drives myelin growt...

Organisms: Mouse

SOPs: No SOPs

Data files: Proteomics analysis of myelin from GLTP KO mous...

Snapshots: No snapshots

Created: 6th Aug 2026 at 13:12, Last updated: 6th Aug 2026 at 13:13

Expression profiling: Spatial Transcriptomics correlated Electron Microscopy (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: A06 - Linking lipid metabolism to inflammation ...

Study: Spatial Transcriptomics-correlated Electron Mic...

Organisms: Mouse

SOPs: No SOPs

Data files: Spatial Transcriptomics correlated Electron Mic...

Snapshots: No snapshots

Created: 6th Aug 2026 at 13:17, Last updated: 6th Aug 2026 at 13:17

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C01 - EPO/EPOR signalling in the recovery from ...

Study: Oligodendrocytes produce amyloid-β and contribu...

Organisms: Mouse

SOPs: No SOPs

Data files: SRP135960, Single-cell transcriptomic profiling of the agi...

Snapshots: No snapshots

Created: 6th Aug 2026 at 13:54, Last updated: 6th Aug 2026 at 14:03

Expression profiling: snRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C01 - EPO/EPOR signalling in the recovery from ...

Study: Oligodendrocytes produce amyloid-β and contribu...

Organisms: Mouse

SOPs: No SOPs

Data files: Single-nuclei transcriptome sequencing of 5xFAD..., Single-nuclei transcriptome sequencing of 5xFAD..., Single-nuclei transcriptome sequencing of mouse...

Snapshots: No snapshots

Created: 6th Aug 2026 at 13:56, Last updated: 6th Aug 2026 at 14:01

Expression profiling: snRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C01 - EPO/EPOR signalling in the recovery from ...

Study: Oligodendrocytes produce amyloid-β and contribu...

Organisms: Human

SOPs: No SOPs

Data files: Altered oligodendrocyte heterogeneity in Multip...

Snapshots: No snapshots

Created: 6th Aug 2026 at 14:05, Last updated: 6th Aug 2026 at 14:06

Expression profiling: snRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C01 - EPO/EPOR signalling in the recovery from ...

Study: Oligodendrocytes produce amyloid-β and contribu...

Organisms: Human

SOPs: No SOPs

Data files: Integrative single-cell analysis of transcripti...

Snapshots: No snapshots

Created: 6th Aug 2026 at 14:07, Last updated: 6th Aug 2026 at 14:08

Expression profiling: scRNA-seq (rat)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: A04 - The role of the meninges in the resolutio...

Study: The lung microbiome regulates brain autoimmunity

Organisms: Rat

SOPs: No SOPs

Data files: Amplicon-based analysis of bacterial communitie..., Transcriptome analysis of lung-derived MBP-spec..., Transcriptome analysis of spinal cord microglia...

Snapshots: No snapshots

Created: 6th Aug 2026 at 14:19, Last updated: 6th Aug 2026 at 14:22

Shotgun proteomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Technology Type

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Pro-inflammatory activation following demyelina...

Organisms: Mouse

SOPs: No SOPs

Data files: Pro-inflammatory activity following demyelinati...

Snapshots: No snapshots

Created: 7th Aug 2026 at 07:31, Last updated: 7th Aug 2026 at 07:34

Shotgun proteomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

Corpus callosum dissections were lysed in 300 µL STET lysis buffer (1% (v/v) Triton X-100, 150 mM NaCl, 2 mM EDTA, 50 mM TrisHCl pH 7.5) with a Precellys Evolution homogenizer (Bertin, Germany) using 0.5 mL soft tissue homogenization kit CK14 applying two cycles of 30 s with a speed of 6500rpm. After 15 min incubation on ice, samples were centrifuged at 16,000×g for 15 min to remove undissolved material and cell debris. The supernatant was transferred to a fresh protein lobind tube (Eppendorf, ...

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Technology Type

Investigation: A06 - Linking lipid metabolism to inflammation ...

Study: Proteomic and lipidomic profiling of demyelinat...

Organisms: Mouse

SOPs: No SOPs

Data files: Proteomic and lipidomic profiling of demyelinat...

Snapshots: No snapshots

Created: 7th Aug 2026 at 07:55, Last updated: 7th Aug 2026 at 07:55

Expression profiling: MERFISH Spatial Transcriptomics (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Single-cell spatial transcriptomic profiling de...

Organisms: Mouse

SOPs: No SOPs

Data files: Single-cell spatial transcriptomic profiling de...

Snapshots: No snapshots

Created: 7th Aug 2026 at 08:10, Last updated: 7th Aug 2026 at 08:11

Expression profiling: scRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Single-cell spatial transcriptomic profiling de...

Organisms: Mouse

SOPs: No SOPs

Data files: Molecular and spatial profiling of multiple scl...

Snapshots: No snapshots

Created: 7th Aug 2026 at 08:12, Last updated: 7th Aug 2026 at 08:12

Expression profiling: MERFISH Spatial Transcriptomics (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Single-cell spatial transcriptomic profiling de...

Organisms: Human

SOPs: No SOPs

Data files: A single-cell resolution spatial transcriptomic...

Snapshots: No snapshots

Created: 7th Aug 2026 at 08:15, Last updated: 7th Aug 2026 at 08:15

Expression profiling: scRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Single-cell spatial transcriptomic profiling de...

Organisms: Human

SOPs: No SOPs

Data files: Single-cell spatial transcriptomic profiling de...

Snapshots: No snapshots

Created: 7th Aug 2026 at 08:16, Last updated: 7th Aug 2026 at 08:17

Expression profiling: snRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B02 - Targeting immunological networks to promo...

Study: A transcriptomic microglia taxonomy across mous...

Organisms: Mouse

SOPs: No SOPs

Data files: A transcriptomic microglia taxonomy across mous...

Snapshots: No snapshots

Created: 7th Aug 2026 at 08:24, Last updated: 7th Aug 2026 at 08:24

Expression profiling: snRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B02 - Targeting immunological networks to promo...

Study: A transcriptomic microglia taxonomy across mous...

Organisms: Human

SOPs: No SOPs

Data files: Spatial map of microglia states across CNS dise...

Snapshots: No snapshots

Created: 7th Aug 2026 at 08:25, Last updated: 7th Aug 2026 at 08:26

Expression profiling: snRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Microglia–neuron crosstalk through Hex–GM2–MGL2...

Organisms: Mouse

SOPs: No SOPs

Data files: Microglia–neuron crosstalk through Hex–GM2–MGL2..., snRNA-seq of Hexb-deficient brain cells, snRNA-seq of Hexb-deficient brain cells upon mi...

Snapshots: No snapshots

Created: 7th Aug 2026 at 10:29, Last updated: 7th Aug 2026 at 10:32

Expression profiling: Bulk RNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Microglia–neuron crosstalk through Hex–GM2–MGL2...

Organisms: Mouse

SOPs: No SOPs

Data files: bulk RNA-seq of Hexb-deficient microglia

Snapshots: No snapshots

Created: 7th Aug 2026 at 10:33, Last updated: 7th Aug 2026 at 10:34

Expression profiling: scRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: B01 - Function of satellite oligodendrocytes in...

Study: Microglia–neuron crosstalk through Hex–GM2–MGL2...

Organisms: Human

SOPs: No SOPs

Data files: snRNA-seq of Sandhoff disease brain cells

Snapshots: No snapshots

Created: 7th Aug 2026 at 10:36, Last updated: 7th Aug 2026 at 10:37

Expression profiling: scRNA-seq (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: A03 - Checkpoints determining recovery from acu...

Study: Mitochondrial calcium uniporter complex control...

Organisms: Human

SOPs: No SOPs

Data files: No Data files

Snapshots: No snapshots

Created: 7th Aug 2026 at 10:44

Mass Spectrometry (human)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Mass Spectrometry

Investigation: A03 - Checkpoints determining recovery from acu...

Study: Mitochondrial calcium uniporter complex control...

Organisms: No organisms

SOPs: No SOPs

Data files: human CD4+ T-cells

Snapshots: No snapshots

Created: 7th Aug 2026 at 10:46, Last updated: 7th Aug 2026 at 10:47

Mass Spectrometry (rat)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Proteomics

Technology type: Mass Spectrometry

Investigation: A03 - Checkpoints determining recovery from acu...

Study: Mitochondrial calcium uniporter complex control...

Organisms: Rat

SOPs: No SOPs

Data files: rat CD4+ T-cells

Snapshots: No snapshots

Created: 7th Aug 2026 at 10:48, Last updated: 7th Aug 2026 at 10:49

Data_Repetitive concussions

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: C03 - Cellular and molecular checkpoints of cir...

Study: Repetitive concussions promote microglia-mediat...

Organisms: Mouse

SOPs: No SOPs

Data files: All data set

Snapshots: No snapshots

Created: 10th Aug 2026 at 07:11, Last updated: 10th Aug 2026 at 07:14

Expression profiling: SuperSeries (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

This SuperSeries is composed of the SubSeries listed below.

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C01 - EPO/EPOR signalling in the recovery from ...

Study: Myelin dysfunction drives amyloid-β deposition ...

Organisms: Mouse

SOPs: No SOPs

Data files: Ageing-associated myelin dysfunction drives amy...

Snapshots: No snapshots

Created: 10th Aug 2026 at 12:08, Last updated: 10th Aug 2026 at 12:10

Expression profiling: Bulk RNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C01 - EPO/EPOR signalling in the recovery from ...

Study: Myelin dysfunction drives amyloid-β deposition ...

Organisms: Mouse

SOPs: No SOPs

Data files: Transcriptome profiling of mouse brain microgli...

Snapshots: No snapshots

Created: 10th Aug 2026 at 12:11, Last updated: 10th Aug 2026 at 12:12

Expression profiling: snRNA-seq (mouse)

TRR 274: Checkpoints of Central Nervous System Recovery

No description specified

Submitter: Camilla Giudici

Assay type: Transcriptomics

Technology type: Sequencing

Investigation: C01 - EPO/EPOR signalling in the recovery from ...

Study: Myelin dysfunction drives amyloid-β deposition ...

Organisms: Mouse

SOPs: No SOPs

Data files: Single-nuclei transcriptome sequencing of 5xFAD..., Single-nuclei transcriptome sequencing of mouse...

Snapshots: No snapshots

Created: 10th Aug 2026 at 12:18, Last updated: 10th Aug 2026 at 12:48

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